Author: Rao, Xiaoquan; Zhao, Shi; Braunstein, Zachary; Mao, Hong; Razavi, Michael; Duan, Lihua; Wei, Yingying; Toomey, Amelia C.; Rajagopalan, Sanjay; Zhong, Jixin
Title: Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways Document date: 2019_2_7
ID: 1n7xjjd5_34
Snippet: To further confirm the dependence of DPP4 up-regulation on CD36, WT or Cd36 −/− BMMs were treated with 25 μg/mL oxLDL and DPP4 expression was measured. As expected, Cd36 −/− BMMs had decreased DPP4 expression after treatment of oxLDL as compared to WT BMMs (Figs. 7a-7d) , suggesting that CD36 is required for oxLDL-induced DPP4 up-regulation. Taken together, oxLDL upregulates DPP4 expression on monocyte and macrophage via TLR4/TRIF and CD.....
Document: To further confirm the dependence of DPP4 up-regulation on CD36, WT or Cd36 −/− BMMs were treated with 25 μg/mL oxLDL and DPP4 expression was measured. As expected, Cd36 −/− BMMs had decreased DPP4 expression after treatment of oxLDL as compared to WT BMMs (Figs. 7a-7d) , suggesting that CD36 is required for oxLDL-induced DPP4 up-regulation. Taken together, oxLDL upregulates DPP4 expression on monocyte and macrophage via TLR4/TRIF and CD36 pathways (Fig. 7e) .
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