Selected article for: "acute respiratory and lung pathological"
Author: Ma, Yuanmei; Zhang, Yu; Liang, Xueya; Lou, Fangfei; Oglesbee, Michael; Krakowka, Steven; Li, Jianrong
Title: Origin, Evolution, and Virulence of Porcine Deltacoronaviruses in the United States
  • Document date: 2015_3_10
    • ID: 6o7j5k9n_29
    Snippet: Unique features of PdCV infection in Gn piglets. Our study found that PdCV has two unique features of infection that are distinct from TGEV and PEDV infection. First, PdCV infection causes epithelial lesions in the glandular pits of the stomach. To our knowledge, involvement of gastric mucosal epithelial cells is not reported for either TGEV or PEDV. There is one report documenting gastric lesions associated with CoV RNAs in severe acute respirat.....
    Document: Unique features of PdCV infection in Gn piglets. Our study found that PdCV has two unique features of infection that are distinct from TGEV and PEDV infection. First, PdCV infection causes epithelial lesions in the glandular pits of the stomach. To our knowledge, involvement of gastric mucosal epithelial cells is not reported for either TGEV or PEDV. There is one report documenting gastric lesions associated with CoV RNAs in severe acute respiratory syndrome (SARS)-convalescent human patients, establishing a precedent for findings (28) . Second, PdCV infection is associated with mild interstitial pneumonia, evident in formalin-inflated lungs. In this regard, mild and ill-defined interstitial lesions in pulmonary parenchyma suggest that PdCV may have an unrecognized PRCV-like respiratory component. Modest amounts PdCV viral RNA were found in lung tissue homogenates, and PdCV antigen was detected in bronchial mucosal epithelial cells. Pathological changes in the lung have not been reported for PEDV and TGEV.

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