Title: Primary sequence domains required for the retention of rotavirus VP7 in the endoplasmic reticulum Document date: 1988_11_1
ID: 63mxzwti_43
Snippet: When the kinetics of secretion of VP7 deletion mutants and also the VP7-amylase chimera were examined, only the secretion of amylase was rapid and complete. The chimera showed a slower turnover time of the intracellular pool and also a less complete turnover into the medium. The transit time of those molecules that were secreted was however, similar (~30-45 min) for all mutants, showing that once the altered VP7s escape the ER their secretion is .....
Document: When the kinetics of secretion of VP7 deletion mutants and also the VP7-amylase chimera were examined, only the secretion of amylase was rapid and complete. The chimera showed a slower turnover time of the intracellular pool and also a less complete turnover into the medium. The transit time of those molecules that were secreted was however, similar (~30-45 min) for all mutants, showing that once the altered VP7s escape the ER their secretion is rapid. These data may be interpreted as a partial function of one or of the other of the VP7 domains in mediating an ER retention.
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