Author: Fausther-Bovendo, Hugues; Kobinger, Gary P
Title: Pre-existing immunity against Ad vectors: Humoral, cellular, and innate response, what's important? Document date: 2014_11_1
ID: 3894l9qi_14
Snippet: It is worth noting that although excessive innate immune responses are detrimental to Ad vector immunogenicity, inflammatory responses are still required to trigger a robust adaptive response and therefore a good vaccine-derived immune response. The requirement for inflammatory responses was illustrated with IFN-a/b-R knockout mice. In these studies, depending on the immunogenicity of the transgene, knockout mice failed to mount cellular response.....
Document: It is worth noting that although excessive innate immune responses are detrimental to Ad vector immunogenicity, inflammatory responses are still required to trigger a robust adaptive response and therefore a good vaccine-derived immune response. The requirement for inflammatory responses was illustrated with IFN-a/b-R knockout mice. In these studies, depending on the immunogenicity of the transgene, knockout mice failed to mount cellular responses 42, 51 or mounted lower responses after Ad5 immunization. 49, 50 Solutions to overcome pre-existing HAd immunity
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