Prevalence of Respiratory Viral Pathogen Testing and Co-Detections Among Patients Hospitalized With Influenza, 2012–2015

Cohen, Jessica; Anderson, Evan J.; Lindegren, Mary Lou; Kirley, Pam Daily; Zansky, Shelley M.; Thomas, Ann; Lynfield, Ruth; Miller, Lisa; Bargsten, Marisa; Meek, James I.; Bennett, Nancy M.; Collins, James; Monroe, Maya; Reed, Gregg M.; Tatham, Lilith; Fry, Alicia M.; Garg, Shikha

Results. In total, 4939 children and 34,837 adults were hospitalized with influenza; 3796 (77%) children and 9863 (28%) adults were tested for at least one additional pathogen. RSV was the most commonly tested pathogen among children (76%) and adults (28%). Among those tested, 687 (18%) children (Figure 1) and 279 (3%) adults (Figure 2) tested positive for ≥1 additional pathogen; the most common pathogen co-detected among children was RSV (11%). Children with co-detections were more likely than those with influenza alone to be <2 years old (aOR 2.8; 95% confidence interval [CI] 2.2–3.6), have bronchiolitis (aOR 5.5; CI 4.4–6.9) or pneumonia (aOR 1.4; CI 1.1–1.7) and be admitted to an ICU (aOR 1.4; CI 1.1–1.7) and less likely to be born prematurely (aOR 0.7; CI 0.5–0.9). Adults with co-detections were more likely than those with influenza alone to be <65 years old (aOR 1.8; CI 1.4–2.3) and immunocompromised (aOR 1.5; CI 1.2–1.9).