Author: Mok, Hoyin; Cheng, Xing; Xu, Qi; Zengel, James R; Parhy, Bandita; Zhao, Jackie; Wang, C. Kathy; Jin, Hong
Title: Evaluation of Measles Vaccine Virus as a Vector to Deliver Respiratory Syncytial Virus Fusion Protein or Epstein-Barr Virus Glycoprotein gp350 Document date: 2012_2_16
ID: 3qdjmb2j_29
Snippet: Cell mediated immune response is important for viral clearance and may play an important role in vaccine mediated protective immune response [44] . RSV F-specific and EBV gp350-specific T cell responses in splenocytes were examined by IFN-and IL-4 ELISpot on day 7 post the 2 nd dose. The frequencies of RSV F-specific IFN-secreting cells were statistically higher in sF3 vaccinated group (average 130 spots/10 6 splenocytes) compared to sF1 vaccinat.....
Document: Cell mediated immune response is important for viral clearance and may play an important role in vaccine mediated protective immune response [44] . RSV F-specific and EBV gp350-specific T cell responses in splenocytes were examined by IFN-and IL-4 ELISpot on day 7 post the 2 nd dose. The frequencies of RSV F-specific IFN-secreting cells were statistically higher in sF3 vaccinated group (average 130 spots/10 6 splenocytes) compared to sF1 vaccinated (average 9 spots/10 6 splenocytes) or RSV A2infected animals (average 45 spots/10 6 splenocytes) (Fig. 3A) . The RSV F-specific IL-4 secreting cells were low, averaged about 20 spots/10 6 splenocytes for both sF1 and sF3 groups. Surprisingly, no RSV-specific IL-4 secreting cells detected in RSV A2-infected animals (Fig. 3C) . Thus, sF3 and RSV induced a Th1-biased response based on the higher IFN-to IL-4 secreting cell ratio.
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