Author: Jorge Blazquez-Prieto; Covadonga Huidobro; Ines Lopez-Alonso; Laura Amado-Rodriguez; Paula Martin-Vicente; Cecilia Lopez-Martinez; Irene Crespo; Cristina Pantoja; Pablo J Fernandez-Marcos; Manuel Serrano; Jacob I Sznajder; Guillermo M Albaiceta
Title: Cellular senescence limits acute lung injury induced by mechanical ventilation Document date: 2020_3_25
ID: ebwxryai_6
Snippet: To explore the main hypothesis, a pooled analysis of published transcriptomic data was performed, using a previously validated 55-gene expression signature of senescence (13) as main endpoint. Datasets reporting lung gene expression in animal models of acute lung injury and mechanical ventilation were obtained from public repositories (Gene Omnibus Expression https://www.ncbi.nlm.nih.gov/geo/-and ArrayExpress https://www.ebi.ac.uk/arrayexpress/-).....
Document: To explore the main hypothesis, a pooled analysis of published transcriptomic data was performed, using a previously validated 55-gene expression signature of senescence (13) as main endpoint. Datasets reporting lung gene expression in animal models of acute lung injury and mechanical ventilation were obtained from public repositories (Gene Omnibus Expression https://www.ncbi.nlm.nih.gov/geo/-and ArrayExpress https://www.ebi.ac.uk/arrayexpress/-) using the following terms: "Stretch", "Cyclic strain", "Mechanical Ventilation", "Lung", and "Alveolar". Fifty-one datasets were manually reviewed. Studies lacking a control group with intact, spontaneously breathing animals and those reporting less than 40 genes from the endpoint signature were excluded, so 11 datasets were finally used (Supplementary Table 1 ).
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