Selected article for: "aberrant complement and acute respiratory failure important cause"
Author: Sun, Shihui; Jiang, Yuting; Wang, Renxi; Liu, Chenfeng; Liu, Xiaoling; Song, Nianping; Guo, Yan; Guo, Renfeng; Du, Lanying; Jiang, Shibo; Li, Yan; Qiu, Zewu; Zhao, Guangyu; Zhou, Yusen
Title: Treatment of Paraquat-Induced Lung Injury With an Anti-C5a Antibody: Potential Clinical Application*
  • Document date: 2018_4_13
    • ID: 6ztwho9k_31
    Snippet: ALI is an important cause of acute respiratory failure and is often associated with damage to multiple organs. Resolution of ALI requires repair of epithelial and endothelial barriers and the removal of inflammatory cells and exudate from the distal airspaces, all of which depend on the balance between inflammatory interactions and molecular signals (36, 37) . Patients with paraquat poisoning develop ALI symptoms and typically die of multiple org.....
    Document: ALI is an important cause of acute respiratory failure and is often associated with damage to multiple organs. Resolution of ALI requires repair of epithelial and endothelial barriers and the removal of inflammatory cells and exudate from the distal airspaces, all of which depend on the balance between inflammatory interactions and molecular signals (36, 37) . Patients with paraquat poisoning develop ALI symptoms and typically die of multiple organ failure (38) . A mouse model of paraquat-induced ALI showed strong activation of the complement system, resulting in tissue damage (12) . Here, we observed aberrant complement activation in patients who had ingested paraquat and in a primate model of paraquat-induced ALI. This suggests that targeting complement activation might be a promising therapeutic approach to ALI induced by chemical agents.

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