Transmission of Respiratory Syncytial Virus Among Children Under 5 Years in Households of Rural Communities, the Philippines

Otomaru, Hirono; Kamigaki, Taro; Tamaki, Raita; Okamoto, Michiko; Alday, Portia Parian; Tan, Alvin Gue; Manalo, Joanna Ina; Segubre-Mercado, Edelwisa; Inobaya, Marianette Tawat; Tallo, Veronica; Lupisan, Socorro; Oshitani, Hitoshi

We further estimated basic reproduction number (R 0 ) and 95% CI by using the Wallinga-Teunis approach [16] . We used the data of the daily new positive case count of children <5 years old and the date of onset of RSV-ARI, including cases who were not included in household analysis. The RSV subgroups that were used for the estimation in each year included (1) RSV-A in 2014 and RSV-B in 2015 for both municipalities and (2) RSV-B in 2014 only for the municipality Kawayan. We used a mean serial interval with the standard deviation obtained through households with multiple RSV-ARI cases. The "EpiEstim" R package were used for these estimations [24] . The time period to be used for estimation was determined for each outbreak by following the instructions in the EpiEstim package. We used Cochran-Armitage trend test for testing linear trend of outcomes. All analyses were performed using R version 3.3.1 [25] .