Author: Bahir, Iris; Fromer, Menachem; Prat, Yosef; Linial, Michal
Title: Viral adaptation to host: a proteome-based analysis of codon usage and amino acid preferences Document date: 2009_10_13
ID: 629kl04a_2
Snippet: All viruses are characterized by very high natural mutation rates, with the RNA viruses displaying an exceptionally high rate (Drake, 1993) . Co-evolution and adaptation of viruses to their hosts were mostly studied by comparing mutations at synonymous and non-synonymous coding sites in specific genes. The fast adaptation of human immunodeficiency virus-1 (HIV-1) to specific HLA-1 epitopes validates the importance of viral evolution at a populati.....
Document: All viruses are characterized by very high natural mutation rates, with the RNA viruses displaying an exceptionally high rate (Drake, 1993) . Co-evolution and adaptation of viruses to their hosts were mostly studied by comparing mutations at synonymous and non-synonymous coding sites in specific genes. The fast adaptation of human immunodeficiency virus-1 (HIV-1) to specific HLA-1 epitopes validates the importance of viral evolution at a population level (Kawashima et al, 2009 ). As of yet, the study of adaptation of viruses toward their hosts has been undertaken for specific viral families, including retroviruses (Bronson and Anderson, 1994) , astroviridae (van Hemert et al, 2007) , mimivirus (Sau et al, 2006) , and bacteriophages (Lucks et al, 2008) , but this has not been systematically investigated for all known viral proteomes.
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