Selected article for: "broad range and syncytial virus"
Author: Ouahrouch, Abdelaaziz; Taourirte, Moha; Schols, Dominique; Snoeck, Robert; Andrei, Graciela; Engels, Joachim W.; Lazrek, Hassan B.
Title: Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates
  • Document date: 2015_11_17
    • ID: 25dwlzpy_16
    Snippet: A series of novel 1,2,3-triazolyl ribosides linked to a-aminophosphonates (4a-j, 5a-j) were successfully prepared in high yield via the Kabachnik-Fields reaction and a Cu(I)-catalyzed alkyne-azide cycloaddition under microwave irradiation. The synthesized compounds were evaluated against a broad range of DNA and RNA viruses, some of them showing modest activity against respiratory syncytial virus (compounds 4b and 4c) and varicella-zoster virus (.....
    Document: A series of novel 1,2,3-triazolyl ribosides linked to a-aminophosphonates (4a-j, 5a-j) were successfully prepared in high yield via the Kabachnik-Fields reaction and a Cu(I)-catalyzed alkyne-azide cycloaddition under microwave irradiation. The synthesized compounds were evaluated against a broad range of DNA and RNA viruses, some of them showing modest activity against respiratory syncytial virus (compounds 4b and 4c) and varicella-zoster virus (compounds 5c, 5f, and 5g).

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