Author: Rao, Xiaoquan; Zhao, Shi; Braunstein, Zachary; Mao, Hong; Razavi, Michael; Duan, Lihua; Wei, Yingying; Toomey, Amelia C.; Rajagopalan, Sanjay; Zhong, Jixin
Title: Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways Document date: 2019_2_7
ID: 1n7xjjd5_36
Snippet: In this paper, we demonstrate an important role of TLR4/TRIF and CD36 pathways in the regulation of DPP4 on monocyte/macrophage lineage. DPP4 expression on macrophages demonstrated heterogeneity of expression with high levels seen in CD36 + cells. OxLDL markedly upregulated DPP4 expression via TLR4/TRIF-and CD36-dependent pathways. Our results suggest an important role for oxidized lipids and inflammatory signaling in DPP4 regulation which may pr.....
Document: In this paper, we demonstrate an important role of TLR4/TRIF and CD36 pathways in the regulation of DPP4 on monocyte/macrophage lineage. DPP4 expression on macrophages demonstrated heterogeneity of expression with high levels seen in CD36 + cells. OxLDL markedly upregulated DPP4 expression via TLR4/TRIF-and CD36-dependent pathways. Our results suggest an important role for oxidized lipids and inflammatory signaling in DPP4 regulation which may provide an integrated mechanism linking abnormal post-prandial glucose metabolism with oxidized lipids and inflammation.
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