Author: Xiao, Rui; Chen, Rongchang
Title: Neutrophil gelatinase-associated lipocalin as a potential novel biomarker for ventilator-associated lung injury Document date: 2017_4_7
ID: 3e72pzui_2
Snippet: Neutrophils (polymorphonuclear leukocytes, PMNs) have been demonstrated to be important in the development and progression of VALI and may lie at the center of a positive feedback loop that results in lung injury (4) . Therefore, PMNs or key mediators of the PMN regulatory signaling pathway may be molecular candidates for the occurrence of VALI (5) . Neutrophil gelatinase-associated lipocalin (NGAL), a 25-kDa protein of the lipocalin family, was .....
Document: Neutrophils (polymorphonuclear leukocytes, PMNs) have been demonstrated to be important in the development and progression of VALI and may lie at the center of a positive feedback loop that results in lung injury (4) . Therefore, PMNs or key mediators of the PMN regulatory signaling pathway may be molecular candidates for the occurrence of VALI (5) . Neutrophil gelatinase-associated lipocalin (NGAL), a 25-kDa protein of the lipocalin family, was originally isolated from specific neutrophil granules (6, 7) . In addition to excretion by activated neutrophils, NGAL may be released in small quantities by epithelial and kidney tubular cells, and during inflammation or injury. Elevated NGAL is an early blood-based marker of acute kidney injury and is detectable within 2-12 h following an ischemic/toxic insult in patients with cardiovascular diseases (8, 9) .
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