Author: Yan, Xiujuan; Li, Yingxiu; Choi, Yun Ho; Wang, Chongyang; Piao, Yihua; Ye, Jing; Jiang, Jingzhi; Li, Liangchang; Xu, Huixian; Cui, Qingsong; Yan, Guanghai; Jin, Minggen
Title: Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats Document date: 2018_10_8
ID: 7ea7ur3b_30
Snippet: The effect of Alprostadil on ACE production was also analyzed by Western blot. OA administration caused a significant increase in ACE expression in the lung tissue when compared with the control group ( Figure 7C , 7D p<0.05). As expected, alprostadil prevented the increase of ACE in OA-induced ARDS rats in a dose-dependent manner, and a significant difference was found when 10 μg/kg alprostadil was administrated ( Figure 7B, 7C) . These results.....
Document: The effect of Alprostadil on ACE production was also analyzed by Western blot. OA administration caused a significant increase in ACE expression in the lung tissue when compared with the control group ( Figure 7C , 7D p<0.05). As expected, alprostadil prevented the increase of ACE in OA-induced ARDS rats in a dose-dependent manner, and a significant difference was found when 10 μg/kg alprostadil was administrated ( Figure 7B, 7C) . These results suggest that alprostadil inhibits the production of ACE in the lung tissue of OA-induced ARDS rats.
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