2017 ACVIM Forum Research Abstract Program

Thirty-two ill dogs (target enrollment 40) have completed the study to date (AS, n = 17; NS, n = 15). Ill dogs had significantly elevated 8-IsoP/Cr versus healthy controls (3660 vs. 2980 pg/ mgCr; P = 0.021). Antioxidant supplementation did not result in significant differences in median endogenous glutathione, cysteine, vitamin E, or selenium concentrations, 8-IsoP/Cr, SPI2 score, or 30 day survival. Interestingly, the NS group had significantly decreased plasma cysteine concentrations at 30 days when compared to baseline (9.62 to 6.95 lM; P = 0.039). These preliminary findings suggest, in this heterogeneous population of ill dogs, combination antioxidant supplementation did not alter redox state or clinical outcome. Eating after intestinal surgery in dogs is variable. In humans, early enteral feeding has been shown to decrease morbidity and reduce the duration of post-operative ileus (POI); POI increases the length of hospitalization. This study evaluated the duration of anorexia and time to discharge in dogs following simple enterotomy (SA), multiple enterotomy (linear foreign body) (LFB) and resection and anastomosis (R&A). Additionally, prokinetic use was evaluated.