Author: Liu, Chunxi; Liu, Tingxian; Yu, Xiaoyue; Gu, Yizhu
Title: A preliminary study on the interaction between Asn-Gly-Arg (NGR)-modified multifunctional nanoparticles and vascular epithelial cells Document date: 2017_4_1
ID: xio0g203_46
Snippet: Bestatin is a potent CD13 inhibitor that can inhibit the activity of APN/CD13 and exert anti-tumor activity 40 . The concentration of 100 μg/mL of bestatin was chosen since it was shown to effectively inhibit enzyme activity of CD13 35 but non-toxic to cells. The results of the inhibition study of CD13 enzyme activity are shown in Fig. 6A . Without bestatin treatment, TPIC could be efficiently internalized by HUVEC, and the positive percentage w.....
Document: Bestatin is a potent CD13 inhibitor that can inhibit the activity of APN/CD13 and exert anti-tumor activity 40 . The concentration of 100 μg/mL of bestatin was chosen since it was shown to effectively inhibit enzyme activity of CD13 35 but non-toxic to cells. The results of the inhibition study of CD13 enzyme activity are shown in Fig. 6A . Without bestatin treatment, TPIC could be efficiently internalized by HUVEC, and the positive percentage was over 99%. After bestatin treatment, TPIC was also efficiently internalized by HUVEC but not be significantly suppressed (P40.05), suggesting the internalization of TPIC by HUVEC was not dependent on the enzyme activity of CD13.
Search related documents:
Co phrase search for related documents- enzyme activity and HUVEC TPIC internalization: 1
- enzyme activity and inhibition study: 1, 2, 3, 4
- enzyme activity and significantly suppress: 1
- enzyme activity and TPIC internalization: 1
- HUVEC TPIC internalization and inhibition study: 1
- HUVEC TPIC internalization and TPIC internalization: 1, 2, 3, 4, 5
- inhibition study and TPIC internalization: 1
Co phrase search for related documents, hyperlinks ordered by date