Author: WU, Hong-Xia; WANG, Hua-Lei; GUO, Xiao-Feng; YANG, Yu-Jiao; MA, Jin-Zhu; WANG, Tie-Cheng; GAO, Yu-Wei; ZHAO, Yong-Kun; YANG, Song-Tao; XIA, Xian-Zhu
Title: Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo Document date: 2013_6_14
ID: sj9k4c3i_2
Snippet: RNAi mediated by small interfering RNAs (siRNAs) is a powerful technology allowing the silencing of genes with great specificity and potency. The RNAi strategy has already been successfully applied to inhibit the replication of many viruses, including hepatitis b virus (HbV) [13] , dengue virus (DNV) [14] , human immunodeficiency virus (HIV) [10] , severe acute respiratory syndrome (SARS) coronavirus [11] and influenza virus [21] . Considering th.....
Document: RNAi mediated by small interfering RNAs (siRNAs) is a powerful technology allowing the silencing of genes with great specificity and potency. The RNAi strategy has already been successfully applied to inhibit the replication of many viruses, including hepatitis b virus (HbV) [13] , dengue virus (DNV) [14] , human immunodeficiency virus (HIV) [10] , severe acute respiratory syndrome (SARS) coronavirus [11] and influenza virus [21] . Considering the potential of RNAi as an antiviral agent, few groups have evaluated RNAi-based antiviral agents against rabies [2, 8] . However, one of the potential limitations for applying this technology is developing an effective and targeted delivery tool.
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