Author: Yamashita, Masamichi
Title: Aspirin Intolerance: Experimental Models for Bed-to-Bench Document date: 2016_12_23
ID: ry6xr4ix_34
Snippet: As described above, some causative substances of AERD may not strongly inhibit COX-1-dependent PG synthesis. We previously observed that the ligands of two well-known nuclear receptors, peroxisome proliferator-activated receptor (PPAR) α and γ, independently reduced cysLT release from stimulated RBL-2H3 mast cell line [58] [59] [60] . This may suggest the possibility of a role of some unknown target(s) of NSAIDs and other causative substances......
Document: As described above, some causative substances of AERD may not strongly inhibit COX-1-dependent PG synthesis. We previously observed that the ligands of two well-known nuclear receptors, peroxisome proliferator-activated receptor (PPAR) α and γ, independently reduced cysLT release from stimulated RBL-2H3 mast cell line [58] [59] [60] . This may suggest the possibility of a role of some unknown target(s) of NSAIDs and other causative substances.
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