Author: Zhou, Haixia; Zhao, Jincun; Perlman, Stanley
Title: Autocrine Interferon Priming in Macrophages but Not Dendritic Cells Results in Enhanced Cytokine and Chemokine Production after Coronavirus Infection Document date: 2010_10_19
ID: qg541qho_22
Snippet: Taken together, our results show that macrophages, long considered a major target for infection with MHV, use both IFNARdependent and -independent pathways to enhance the inflammatory milieu at sites of infection and that these pathways are preferentially activated in these cells compared to DC or fibroblasts. Combined with previous studies (50), they suggest that macrophages are an attractive target for modulating the immune response to enhance .....
Document: Taken together, our results show that macrophages, long considered a major target for infection with MHV, use both IFNARdependent and -independent pathways to enhance the inflammatory milieu at sites of infection and that these pathways are preferentially activated in these cells compared to DC or fibroblasts. Combined with previous studies (50), they suggest that macrophages are an attractive target for modulating the immune response to enhance virus clearance while minimizing immunopathological disease.
Search related documents:
Co phrase search for related documents- immune response and inflammatory milieu: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- immune response and major target: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- immune response and MHV infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35
- immune response and previous study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46
- immune response and result macrophage: 1, 2, 3, 4
- immune response and virus clearance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- immune response and virus clearance enhance: 1
- immunopathological disease and virus clearance: 1, 2, 3, 4
- infection site and major target: 1, 2, 3
- infection site and MHV infection: 1, 2
- infection site and previous study: 1, 2, 3, 4, 5, 6, 7
- infection site and virus clearance: 1, 2, 3, 4, 5
- inflammatory milieu and virus clearance: 1, 2
- major target and MHV infection: 1, 2
- major target and MHV infection major target: 1
- major target and previous study: 1
- MHV infection and previous study: 1
- MHV infection and virus clearance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- previous study and virus clearance: 1
Co phrase search for related documents, hyperlinks ordered by date