Cassiae semen: A review of its phytochemistry and pharmacology

Dong, Xiaoxv; Fu, Jing; Yin, Xingbin; Yang, Chunjing; Zhang, Xin; Wang, Wenping; Du, Xueying; Wang, Qingling; Ni, Jian

Drever et al (79) demonstrated that treatment with C. obtusifolia (0.1-10 µg/ml) significantly attenuated secondary calcium dysregulation and cell death induced by N-methyl-D-aspartate and 3-nitropropionic acid in mouse hippocampal cultures, and no significant effect on cell death was induced by incubation with naturally-secreted oligomers of amyloid (A)β. Yi et al (80) reported for the first time, that C. obtusifolia (10 µg/ml) ameliorated the Aβ-induced synaptic dysfunction model through anti-inflammatory and protein kinase B (Akt)/glycogen synthase kinase-3β pathways. The results suggested that the neuroprotective effect may be attributable to obtusifolin (compound 9) and/or alaternin (compound 17) (80) . In a further experiment, C. obtusifolia (0.1-1 µg/ml) inhibited cell damage against oxidopamine (6-OHDA)-induced dopaminergic (DA) neural toxicity in PC12 cells through an anti-oxidant and antimitochondrial-mediated apoptosis mechanism. In a mesencephalic DA culture, C. obtusifolia (0.1-1 µg/ml) protected the DA cells against 6-OHDA-and N-methyl-4-phenylpyridinium iodide-induced