Author: Sullivan, Meghan; Kaur, Kaval; Pauli, Noel; Wilson, Patrick C.
Title: Harnessing the immune system's arsenal: producing human monoclonal antibodies for therapeutics and investigating immune responses Document date: 2011_8_1
ID: qh6ybagu_16
Snippet: Unfortunately, the power of phage-display monoclonal antibody technology is also its potential weakness: these antibodies are produced in the laboratory, not the human body. Thus, these antibodies are not vetted by natural mechanisms to avoid autoimmunity, increasing the chances for unwanted or dangerous side effects. Also, this technology relies on screening against known antigens, limiting its application for the discovery of new antigens. None.....
Document: Unfortunately, the power of phage-display monoclonal antibody technology is also its potential weakness: these antibodies are produced in the laboratory, not the human body. Thus, these antibodies are not vetted by natural mechanisms to avoid autoimmunity, increasing the chances for unwanted or dangerous side effects. Also, this technology relies on screening against known antigens, limiting its application for the discovery of new antigens. Nonetheless, a number of important human therapeutics generated by phage display have either been licensed or are currently in clinical trials, and its applications for epitope discovery to identify better ways to neutralize pathogens are unquestionable.
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