Author: Alexander Rosenberg; Iuliana V. Ene; Maayan Bibi; Shiri Zakin; Ella Shtifman Segal; Naomi Ziv; Alon M. Dahan; Arnaldo L. Colombo; Richard J. Bennett; Judith Berman
Title: Clearing the FoG: Antifungal tolerance is a subpopulation effect that is distinct from resistance and is associated with persistent candidemia Document date: 2017_10_20
ID: begn4tsd_5
Snippet: Based on the assumption that the steady state drug levels are influenced by both drug 215 efflux and uptake, we measured efflux of rhodamine-6-G (R6G), a dye removed primarily via the 216 ABC class of transporters 82 . In general, the rate of R6G efflux was higher in the presence, than 217 in the absence, of FLC, with SC5314 as the notable exception ( Fig. 3f and Supplementary Fig. 218 6a ). Yet, efflux rates did not correlate with FoG under .....
Document: Based on the assumption that the steady state drug levels are influenced by both drug 215 efflux and uptake, we measured efflux of rhodamine-6-G (R6G), a dye removed primarily via the 216 ABC class of transporters 82 . In general, the rate of R6G efflux was higher in the presence, than 217 in the absence, of FLC, with SC5314 as the notable exception ( Fig. 3f and Supplementary Fig. 218 6a ). Yet, efflux rates did not correlate with FoG under any of the conditions tested 219 ( Supplementary Fig. 6b , R 2 < 0.2). Thus, the determinants of steady state intracellular FLC 220 levels are complex, and include uptake and efflux rates as well as other factors (Fig. 3g ).
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