Author: DiMaio, Daniel
Title: Is Virology Dead? Document date: 2014_3_25
ID: ykb2s5ja_4
Snippet: The success of virology enabled the ascendancy of other fields. Restriction mapping, gene transfer into animal cells, directed mutagenesis, and whole-genome sequencing were developed to analyze small viral genomes (7) (8) (9) (10) (11) (12) (13) (14) . These powerful methods ushered in the recombinant DNA era and were in turn applied to studying cellular genes as well. In fact, much of genetic engineering, at least in the early days, centered on .....
Document: The success of virology enabled the ascendancy of other fields. Restriction mapping, gene transfer into animal cells, directed mutagenesis, and whole-genome sequencing were developed to analyze small viral genomes (7) (8) (9) (10) (11) (12) (13) (14) . These powerful methods ushered in the recombinant DNA era and were in turn applied to studying cellular genes as well. In fact, much of genetic engineering, at least in the early days, centered on converting the much larger cellular genomes into virus-sized bits of genetic information, which could then be analyzed by the methods used so successfully on the viruses themselves. With the adoption of molecular cloning techniques by cell biologists and geneticists, virologists no longer had a monopoly on insights into the innermost workings of cells. Now that we can clone and study cellular genes and have sophisticated methods to analyze cells and whole organisms, so the argument goes, why settle for studying viruses?
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