Author: Gu, Jiang; Gong, Encong; Zhang, Bo; Zheng, Jie; Gao, Zifen; Zhong, Yanfeng; Zou, Wanzhong; Zhan, Jun; Wang, Shenglan; Xie, Zhigang; Zhuang, Hui; Wu, Bingquan; Zhong, Haohao; Shao, Hongquan; Fang, Weigang; Gao, Dongshia; Pei, Fei; Li, Xingwang; He, Zhongpin; Xu, Danzhen; Shi, Xeying; Anderson, Virginia M.; Leong, Anthony S.-Y.
Title: Multiple organ infection and the pathogenesis of SARS Document date: 2005_8_1
ID: rqjeacow_1
Snippet: The target organ of severe acute respiratory syndrome (SARS) is widely believed to be the lungs, hence the names "severe acute respiratory syndrome" and "SARS atypical pneumonia" (1, 2) . However, patients often have evidence of other organ dysfunction, including gastrointestinal symptoms (3), abnormal liver function (4, 5) , splenic atrophy, and lymphadenopathy (6) . This may reflect widespread immunopathology or the presence of extrapulmonary S.....
Document: The target organ of severe acute respiratory syndrome (SARS) is widely believed to be the lungs, hence the names "severe acute respiratory syndrome" and "SARS atypical pneumonia" (1, 2) . However, patients often have evidence of other organ dysfunction, including gastrointestinal symptoms (3), abnormal liver function (4, 5) , splenic atrophy, and lymphadenopathy (6) . This may reflect widespread immunopathology or the presence of extrapulmonary SARS-coronavirus (CoV) dissemination and replication, as has been observed in other species infected with animal coronavirus (7) . Recent reports of multiple organ infection by the virus were based mostly on partial autopsies (8) . A comprehensive theory of pathogenesis for this newly emerged infectious disease is lacking.
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