Author: Choi, Kang-Seuk
Title: Newcastle disease virus vectored vaccines as bivalent or antigen delivery vaccines Document date: 2017_7_26
ID: vk59ghjm_29
Snippet: Bivalent NDV-vectored vaccines, which have been developed to prevent diseases of economic importance to the poultry industry, have advantages over traditional vaccines (Table 3) . Examples include infectious bursal disease virus (IBDV) [52] , infectious bronchitis virus (IBV) [53] , infectious laryngotrachitis virus (ILTV) [54, 55] , and avian metapneumovirus (aMPV) [57] . IBDV, a birnavirus that infects chickens, is an important pathogen that ca.....
Document: Bivalent NDV-vectored vaccines, which have been developed to prevent diseases of economic importance to the poultry industry, have advantages over traditional vaccines (Table 3) . Examples include infectious bursal disease virus (IBDV) [52] , infectious bronchitis virus (IBV) [53] , infectious laryngotrachitis virus (ILTV) [54, 55] , and avian metapneumovirus (aMPV) [57] . IBDV, a birnavirus that infects chickens, is an important pathogen that causes severe immunosuppression and high mortality in young chickens. Live attenuated vaccines of moderate virulence (especially widely used intermediate plus vaccines) are used widely to prevent infectious bursal disease (IBD); however, they can cause severe side effects (symptoms consistent with IBD) in young chickens. Huang et al. [52] developed a NDV-vectored IBDV vaccine (rLaSota/VP2) expressing the VP2 gene of IBDV, which is responsible for protective immunity against IBDV. The VP2 gene is inserted into the 3´end non-coding region of the NDV genome. The live IBV vaccine is very safe in young chickens and protects SPF chickens against virulent NDV and virulent IBDV.
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