Selected article for: "acute respiratory syndrome and long noncoding rnas"
Author: Chang, Stewart T.; Sova, Pavel; Peng, Xinxia; Weiss, Jeffrey; Law, G. Lynn; Palermo, Robert E.; Katze, Michael G.
Title: Next-Generation Sequencing Reveals HIV-1-Mediated Suppression of T Cell Activation and RNA Processing and Regulation of Noncoding RNA Expression in a CD4(+) T Cell Line
  • Document date: 2011_9_20
    • ID: zyzgk2z3_24
    Snippet: HIV infection and host noncoding RNA. In this study, we used NGS to measure all of the polyadenylated RNAs in CD4 Ï© T lymphoblasts infected with intact, replication-competent HIV. NGS offers a number of potential benefits to the study of viral infections; among them is the ability to detect non-protein-coding RNAs expressed during infection. In a previous study, we used NGS to detect long noncoding RNAs in the lungs of severe acute respiratory s.....
    Document: HIV infection and host noncoding RNA. In this study, we used NGS to measure all of the polyadenylated RNAs in CD4 Ï© T lymphoblasts infected with intact, replication-competent HIV. NGS offers a number of potential benefits to the study of viral infections; among them is the ability to detect non-protein-coding RNAs expressed during infection. In a previous study, we used NGS to detect long noncoding RNAs in the lungs of severe acute respiratory syndrome (SARS) coronavirus (CoV)-infected mice (8) . Many of these RNAs were found to be differentially expressed, and unique signatures of infection could be identified (8) .

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