Selected article for: "cell cell and eventual death"
Author: Chang, Stewart T.; Thomas, Matthew J.; Sova, Pavel; Green, Richard R.; Palermo, Robert E.; Katze, Michael G.
Title: Next-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection
  • Document date: 2013_2_5
    • ID: t98g8z7i_1
    Snippet: During periods of active viral replication, these changes occur in multiple classes of molecules, including mRNAs and proteins (1, 2) . Infected cells exhibit decreased basic functionality, e.g., in cell signaling (3) , culminating in the eventual death of the cell. Using next-generation sequencing (NGS), we recently profiled the transcriptome of HIV-infected lymphoblastoid cells and found that over half of the detectable polyadenylated RNA speci.....
    Document: During periods of active viral replication, these changes occur in multiple classes of molecules, including mRNAs and proteins (1, 2) . Infected cells exhibit decreased basic functionality, e.g., in cell signaling (3) , culminating in the eventual death of the cell. Using next-generation sequencing (NGS), we recently profiled the transcriptome of HIV-infected lymphoblastoid cells and found that over half of the detectable polyadenylated RNA species were differentially expressed (DE) during infection (1) . These changes corroborated clinical results. For example, in CD4 Ï© T cells isolated from HIV Ï© individuals, a distinct expression profile was observed comprising 260 genes whose expression correlated with viral load; these genes were involved in a variety of functions, including inflammatory signaling, cell cycle, and antigen presentation (4) .

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