Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017

Disclosures: No disclosures to report. from granulocytes. Increased concentrations of canine S100A12 (cA12) in feces and serum were found in dogs with CE. Intestinal mucosal MPO activities have been reported to be increased in humans with inflammatory bowel disease (IBD) and also in animal models of human IBD. However, intestinal mucosal cA12 and MPO have not been investigated in dogs with CE. We evaluated the levels of mucosal cA12 and MPO in dogs with CE in comparison with healthy dogs using an enzyme-linked immunoassay and a spectrophotometric method, respectively. Additionally, we assessed the association of mucosal cA12 and MPO levels with the canine clinical IBD activity index (CIBDAI), histopathologic findings, clinical outcome, and serum albumin concentration. Intestinal mucosal biopsies were collected from 40 dogs with CE (duodenum [n = 35], ileum [n = 12], colon [n = 15], and cecum [n = 6]). Historical intestinal tissue samples from 18 healthy beagle dogs served as controls (duodenum, ileum, and colon [n = 18, each] and cecum [n = 6]). Data are presented as medians (interquartile range).