RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS

Chronic inflammatory enteropathies (CIE) are an important group of diseases in dogs, and the innate immunity plays a key role in CIE pathogenesis. The receptor of advanced glycation end products (RAGE), which belongs to the innate immune system, is a pattern‐recognition receptor recognizing pathogen‐associated and endogenous molecular structures released with inflammation or tissue damage. In a pilot study, systemic concentrations of the decoy receptor sRAGE (soluble RAGE) were decreased in dogs with CIE and normalized only in those dogs with clinical remission after induction therapy. However, the association between serum sRAGE, disease severity, and other inflammatory biomarkers has not been extensively studied in canine CIE. This study aimed to evaluate serum sRAGE concentrations in a large group of dogs with CIE.