Title: Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target Document date: 1994_2_1
ID: s0bfhwtn_10
Snippet: Cells expressing high levels of myc proliferate at a faster rate than their normal untransformed counterparts and bypass Go by entering G1 from mitosis (12) (13) (14) . If the Go state protects cells from CTL-induced apoptosis, as it does in growth factor deprivation-and p53-induced apoptosis (15, 16) , one would predict that c-myc-transformed cells would be more susceptible to apoptosis because they do not enter Go. We transinfected the 3T3-A31 .....
Document: Cells expressing high levels of myc proliferate at a faster rate than their normal untransformed counterparts and bypass Go by entering G1 from mitosis (12) (13) (14) . If the Go state protects cells from CTL-induced apoptosis, as it does in growth factor deprivation-and p53-induced apoptosis (15, 16) , one would predict that c-myc-transformed cells would be more susceptible to apoptosis because they do not enter Go. We transinfected the 3T3-A31 cells with a c-myc containing retrovirus (17) and selected a transformant in soft agar. In the presence of 10% FBS, the population doubling time of these cells (ta) was 12 _+ 1 h vs. 20 _+ 2 h for the parental 3T3-A31 cells.
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