Author: Schrom, Eva; Huber, Maja; Aneja, Manish; Dohmen, Christian; Emrich, Daniela; Geiger, Johannes; Hasenpusch, Günther; Herrmann-Janson, Annika; Kretzschmann, Verena; Mykhailyk, Olga; Pasewald, Tamara; Oak, Prajakta; Hilgendorff, Anne; Wohlleber, Dirk; Hoymann, Heinz-Gerd; Schaudien, Dirk; Plank, Christian; Rudolph, Carsten; Kubisch-Dohmen, Rebekka
Title: Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA Document date: 2017_4_13
ID: tulmnb32_3
Snippet: In our first set of experiments, we investigated RNA delivery of in vitro-transcribed chemically modified ACE2 RNA and its successful translation into ACE2 protein. As a generic test system, we chose HEK293 human embryonic kidney cells, which are frequently used for transient transfection experiments. With the aim of liver-and lung-targeted protein translation in subsequent in vivo studies, we selected A549 alveolar epithelial cells (AECs) and He.....
Document: In our first set of experiments, we investigated RNA delivery of in vitro-transcribed chemically modified ACE2 RNA and its successful translation into ACE2 protein. As a generic test system, we chose HEK293 human embryonic kidney cells, which are frequently used for transient transfection experiments. With the aim of liver-and lung-targeted protein translation in subsequent in vivo studies, we selected A549 alveolar epithelial cells (AECs) and HepG2 hepatoma cells as representative human cell lines and hepatocytes and lung fibroblasts as representative primary murine cells.
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