Author: Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Chan, Chris Chung-Sing; Yip, Cyril Chik-Yan; Mak, Winger Wing-Nga; Zhu, Houshun; Poon, Vincent Kwok-Man; Tee, Kah-Meng; Zhu, Zheng; Cai, Jian-Piao; Tsang, Jessica Oi-Ling; Chik, Kenn Ka-Heng; Yin, Feifei; Chan, Kwok-Hung; Kok, Kin-Hang; Jin, Dong-Yan; Au-Yeung, Rex Kwok-Him; Yuen, Kwok-Yung
Title: Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons Document date: 2016_11_12
ID: v4r5d26a_1
Snippet: Zika virus (ZIKV) is an emerging flavivirus that has been largely neglected for N 60 years after its discovery due to its restricted geographical distribution and its presumed low clinical significance (Chan et al., 2016a) . Since 2007, large-scale outbreaks of ZIKV infection have occurred in the Pacific islands, Latin America, and most recently, USA and Southeast Asia (Duffy et al., 2009; Musso and Gubler, 2016; Zhu et al., 2016) . As of 27 Octo.....
Document: Zika virus (ZIKV) is an emerging flavivirus that has been largely neglected for N 60 years after its discovery due to its restricted geographical distribution and its presumed low clinical significance (Chan et al., 2016a) . Since 2007, large-scale outbreaks of ZIKV infection have occurred in the Pacific islands, Latin America, and most recently, USA and Southeast Asia (Duffy et al., 2009; Musso and Gubler, 2016; Zhu et al., 2016) . As of 27 October 2016, N 70 countries/territories have EBioMedicine 14 (2016) 112-122 reported continuing mosquito-borne transmission of ZIKV (World Health Organization. Zika situation report. October 27, 2016) . In addition to mosquito-borne transmission, sexual and transplacental transmissions of ZIKV have also been reported (Chan et al., 2016a; Musso et al., 2015a; Foy et al., 2011; Calvet et al., 2016) . These non-vectorborne transmission routes render the control of the continuing epidemic more complicated.
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