Selected article for: "correct targeting and transmembrane domain"

Title: Yeast Kex1p is a Golgi-associated membrane protein: deletions in a cytoplasmic targeting domain result in mislocalization to the vacuolar membrane
  • Document date: 1992_12_2
  • ID: ucguzgdm_55
    Snippet: Previous work has demonstrated the role that cytoplasmic domains of transmembrane proteins play in the retention and targeting of proteins within the secretory pathway. A consensus retention motif has been identified at the termini of the cytoplasmically exposed domain of mammalian ER resident type I transmembrane proteins (Nilsson et al., 1989; Jackson et al., 1990) . The cytoplasmic domains of the transferrin receptor, cation-independent mannos.....
    Document: Previous work has demonstrated the role that cytoplasmic domains of transmembrane proteins play in the retention and targeting of proteins within the secretory pathway. A consensus retention motif has been identified at the termini of the cytoplasmically exposed domain of mammalian ER resident type I transmembrane proteins (Nilsson et al., 1989; Jackson et al., 1990) . The cytoplasmic domains of the transferrin receptor, cation-independent mannose-6-phosphate receptor, and the lysosomal acid phosphatase are involved in the correct targeting or endocytosis of these proteins (Rothenberger et al., 1987; Lobel et al., 1989; Peters et al., 1990) .

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