Author: Carter, Chris J.
Title: Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease Document date: 2017_9_28
ID: tmpidjrp_50
Snippet: In summary, AD susceptibility genes appear to have been subject to positive selective pressure. This may relate to their ability to convey general resistance to dangerous pathogens over evolutionary time, and this may in turn relate to enhanced immune/inflammatory responses to pathogens. Many AD gene variants converge towards an enhanced production of Aâ¤, and as this peptide has potent broad-spectrum antimicrobial effects, this may also confer .....
Document: In summary, AD susceptibility genes appear to have been subject to positive selective pressure. This may relate to their ability to convey general resistance to dangerous pathogens over evolutionary time, and this may in turn relate to enhanced immune/inflammatory responses to pathogens. Many AD gene variants converge towards an enhanced production of Aâ¤, and as this peptide has potent broad-spectrum antimicrobial effects, this may also confer an evolutionary advantage.
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