Author: Agnihothram, Sudhakar; Yount, Boyd L.; Donaldson, Eric F.; Huynh, Jeremy; Menachery, Vineet D.; Gralinski, Lisa E.; Graham, Rachel L.; Becker, Michelle M.; Tomar, Sakshi; Scobey, Trevor D.; Osswald, Heather L.; Whitmore, Alan; Gopal, Robin; Ghosh, Arun K.; Mesecar, Andrew; Zambon, Maria; Heise, Mark; Denison, Mark R.; Baric, Ralph S.
Title: A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant Document date: 2014_3_25
ID: y4zoyqua_16
Snippet: We then determined whether VRP vaccines expressing the S proteins of other group 2c â¤-CoVs (BtCoV HKU4 or HKU5 or MERS-CoV) provided cross-protection against BtCoV HKU5-SE replication in vivo. Analysis of viral replication at 2 days p.i. indicated that none of these vaccines elicited cross-protection (see Fig. S3A in the supplemental material). Our results are consistent with a recent report showing the absence of cross-neutralization using SAR.....
Document: We then determined whether VRP vaccines expressing the S proteins of other group 2c â¤-CoVs (BtCoV HKU4 or HKU5 or MERS-CoV) provided cross-protection against BtCoV HKU5-SE replication in vivo. Analysis of viral replication at 2 days p.i. indicated that none of these vaccines elicited cross-protection (see Fig. S3A in the supplemental material). Our results are consistent with a recent report showing the absence of cross-neutralization using SARS-CoV S-specific antibodies against full-length MERS-CoV S or its RBD (26) .
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