Author: Nicholls, John M
Title: The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract Document date: 2013_3_29
ID: vyci1ho3_16
Snippet: The influence of SP-D on the innate immune response has been studied in SP-D deficient mice, which showed enhanced viral replication of glycosylated influenza virus. This change can be rectified if there is overexpression of wild type SP-D proteins [39] . Reading and colleagues have further shown that elevated glucose can interact with SP-D resulting in more severe disease in diabetic mice [40] . This finding is of note when it was found that pat.....
Document: The influence of SP-D on the innate immune response has been studied in SP-D deficient mice, which showed enhanced viral replication of glycosylated influenza virus. This change can be rectified if there is overexpression of wild type SP-D proteins [39] . Reading and colleagues have further shown that elevated glucose can interact with SP-D resulting in more severe disease in diabetic mice [40] . This finding is of note when it was found that patients with diabetes or obesity were more prone to developing severe disease in the 2009 pandemic [41] .
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