Author: Evans, Claire F.; Horwitz, Marc S.; Hobbs, Monte V.; Oldstone, Michael B.A.
Title: Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease Document date: 1996_12_1
ID: t82a9y5s_1
Snippet: T he concept of molecular mimicry has been proposed for the etiology of autoimmune diseases (1) (2) (3) (4) (5) . In molecular mimicry, a pathogen such as a virus shares peptide sequences or conformations with a host protein. The immune response to the viral infection results in a cross-reactive autoimmune attack against a target tissue expressing the mimicked protein. To date, molecular mimicry has been suggested to play a role in the pathogenes.....
Document: T he concept of molecular mimicry has been proposed for the etiology of autoimmune diseases (1) (2) (3) (4) (5) . In molecular mimicry, a pathogen such as a virus shares peptide sequences or conformations with a host protein. The immune response to the viral infection results in a cross-reactive autoimmune attack against a target tissue expressing the mimicked protein. To date, molecular mimicry has been suggested to play a role in the pathogenesis of several human diseases, including insulin-dependent diabetes mellitus (6) , ankylosing spondylitis (7), Guillain-Barre syndrome (8) , primary biliary cirrhosis (9) , and multiple sclerosis (MS) 1 (10) (11) (12) , but has yet to be conclusively shown to be the initiating factor of these autoimmune diseases.
Search related documents:
Co phrase search for related documents- autoimmune attack and molecular mimicry: 1, 2
- autoimmune attack and MS multiple sclerosis: 1
- autoimmune attack and multiple sclerosis: 1, 2
- autoimmune disease and biliary cirrhosis: 1, 2, 3, 4
- autoimmune disease and Guillain Barre syndrome: 1, 2, 3, 4, 5, 6
- autoimmune disease and host protein: 1, 2, 3, 4
- autoimmune disease and human disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- autoimmune disease and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- autoimmune disease and insulin dependent diabetes: 1, 2, 3, 4, 5, 6, 7, 8
- autoimmune disease and insulin dependent diabetes mellitus: 1, 2, 3, 4, 5, 6
- autoimmune disease and mimic protein: 1
- autoimmune disease and molecular mimicry: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- autoimmune disease and MS multiple sclerosis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- autoimmune disease and multiple sclerosis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- autoimmune disease etiology and human disease: 1
- autoimmune disease etiology and immune response: 1
- autoimmune disease etiology and molecular mimicry: 1, 2
- autoimmune disease etiology and MS multiple sclerosis: 1, 2
- autoimmune disease etiology and multiple sclerosis: 1, 2
Co phrase search for related documents, hyperlinks ordered by date