Title: Yeast Kex1p is a Golgi-associated membrane protein: deletions in a cytoplasmic targeting domain result in mislocalization to the vacuolar membrane Document date: 1992_12_2
ID: ucguzgdm_65
Snippet: Given the results presented here, we favor models 3 and 4 which are variants of each other in that both result in the delivery of Kexlp to the vacuole by default (no positive targeting signal involved) but differ in the delivery route. Model 4, involving a direct Golgi-to-vacuole route, may be the most likely as delivery of the vacuolar membrane protein DPAP B does not involve transport to the plasma membrane and subsequent endocytosis (Roberts e.....
Document: Given the results presented here, we favor models 3 and 4 which are variants of each other in that both result in the delivery of Kexlp to the vacuole by default (no positive targeting signal involved) but differ in the delivery route. Model 4, involving a direct Golgi-to-vacuole route, may be the most likely as delivery of the vacuolar membrane protein DPAP B does not involve transport to the plasma membrane and subsequent endocytosis (Roberts et al., 1992) . In addition, Kexlp-Bcl contains no cytoplasmic tail to participate in classical endocytosis.
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