Author: Dawson, Patrick; Malik, Mamunur Rahman; Parvez, Faruque; Morse, Stephen S.
Title: What Have We Learned About Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review Document date: 2019_3_1
ID: yb54i1ne_52
Snippet: High-throughput screening and other methods have identified additional promising compounds in several classes , de Wilde et al. 2013 , Gao et al. 2013 , Shirato et al. 2013 , Adedeji et al. 2014 , Lundin et al. 2014 , Tao et al. 2014 , Wrensch et al. 2014 , Corti et al. 2015 , Liu et al. 2015 . These include inhibitors against both viral (Kilianski et al. 2013 , Lei et al. 2014 , Kumar et al. 2017 ) and host (Gierer et al. 2015) proteases needed .....
Document: High-throughput screening and other methods have identified additional promising compounds in several classes , de Wilde et al. 2013 , Gao et al. 2013 , Shirato et al. 2013 , Adedeji et al. 2014 , Lundin et al. 2014 , Tao et al. 2014 , Wrensch et al. 2014 , Corti et al. 2015 , Liu et al. 2015 . These include inhibitors against both viral (Kilianski et al. 2013 , Lei et al. 2014 , Kumar et al. 2017 ) and host (Gierer et al. 2015) proteases needed to process the virus. However, it was reported that inhibiting proprotein convertases inhibits host cell processing of the spike protein but did not affect viral infectivity or cell-to-cell spread (Gierer et al. 2015) .
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