Author: Liao, Pei-Yu; Choi, Yong Seok; Dinman, Jonathan D.; Lee, Kelvin H.
Title: The many paths to frameshifting: kinetic modelling and analysis of the effects of different elongation steps on programmed –1 ribosomal frameshifting Document date: 2010_9_7
ID: wwq0sd2r_29
Snippet: In Pathway II, À1 PRF occurs during aa-tRNA accommodation and the slippage occurs before peptidyltransfer. Figure 6a shows that a higher k pas2 results in a higher FS%. Interestingly, the larger FS% results from an increase in FS z while the level of FS m remains at a similar level (Figure 6a) . Therefore, the fraction of FS m is predicted to decrease as k pas2 increases ( Figure 6b) . Here, the majority of FS z is generated from Pathway III whe.....
Document: In Pathway II, À1 PRF occurs during aa-tRNA accommodation and the slippage occurs before peptidyltransfer. Figure 6a shows that a higher k pas2 results in a higher FS%. Interestingly, the larger FS% results from an increase in FS z while the level of FS m remains at a similar level (Figure 6a) . Therefore, the fraction of FS m is predicted to decrease as k pas2 increases ( Figure 6b) . Here, the majority of FS z is generated from Pathway III when k pas2 is <3 s À1 , while the majority of FS z is produced from pathway II when k pas2 is >3 s À1 (Figure 6b) .
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