Author: Yan, Xisheng; Li, Fen; Wang, Xiao; Yan, Jie; Zhu, Fen; Tang, Shifan; Deng, Yingzhong; Wang, Hua; Chen, Rui; Yu, Zhili; Li, Yaping; Shang, Jingzhou; Zeng, Lingjun; Zhao, Jie; Guan, Chaokun; Liu, Qiaomei; Chen, Haifeng; Gong, Wei; Huang, Xin; Zhang, Yuâ€Jiao; Liu, Jianguang; Dong, Xiaoyan; Zheng, Wen; Nie, Shaoping; Li, Dongsheng
Title: Neutrophil to lymphocyte ratio as prognostic and predictive factor in patients with coronavirus disease 2019: A retrospective crossâ€sectional study Cord-id: bph0ro5v Document date: 2020_6_9
ID: bph0ro5v
Snippet: This retrospective study was designed to explore whether neutrophil to lymphocyte ratio (NLR) is a prognostic factor in patients with coronavirus disease 2019 (COVIDâ€19). A cohort of patients with COVIDâ€19 admitted to the Tongren Hospital of Wuhan University from 11 January 2020 to 3 March 2020 was retrospectively analyzed. Patients with hematologic malignancy were excluded. The NLR was calculated by dividing the neutrophil count by the lymphocyte count. NLR values were measured at the time
Document: This retrospective study was designed to explore whether neutrophil to lymphocyte ratio (NLR) is a prognostic factor in patients with coronavirus disease 2019 (COVIDâ€19). A cohort of patients with COVIDâ€19 admitted to the Tongren Hospital of Wuhan University from 11 January 2020 to 3 March 2020 was retrospectively analyzed. Patients with hematologic malignancy were excluded. The NLR was calculated by dividing the neutrophil count by the lymphocyte count. NLR values were measured at the time of admission. The primary outcome was allâ€cause inâ€hospital mortality. A multivariate logistic analysis was performed. A total of 1004 patients with COVIDâ€19 were included in this study. The mortality rate was 4.0% (40 cases). The median age of nonsurvivors (68 years) was significantly older than survivors (62 years). Male sex was more predominant in nonsurvival group (27; 67.5%) than in the survival group (466; 48.3%). NLR value of nonsurvival group (median: 49.06; interquartile range [IQR]: 25.71â€69.70) was higher than that of survival group (median: 4.11; IQR: 2.44â€8.12; P < .001). In multivariate logistic regression analysis, after adjusting for confounding factors, NLR more than 11.75 was significantly correlated with allâ€cause inâ€hospital mortality (odds ratio = 44.351; 95% confidence interval = 4.627â€425.088). These results suggest that the NLR at hospital admission is associated with inâ€hospital mortality among patients with COVIDâ€19. Therefore, the NLR appears to be a significant prognostic biomarker of outcomes in critically ill patients with COVIDâ€19. However, further investigation is needed to validate this relationship with data collected prospectively.
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