Author: Christine Dahlke; Jasmin Heidepriem; Robin Kobbe; Rene Santer; Till Koch; Anahita Fathi; My L. Ly; Stefan Schmiedel; Peter H. Seeberger; Marylyn M. Addo; Felix F. Loeffler
Title: Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series Document date: 2020_4_17
ID: icl1t9d6_23
Snippet: To evaluate the kinetics of B-cell epitopes during the mild and severe course of COVID-19, we used full-proteome peptide microarrays (see Supporting Information for complete microarray data). As a general trend, we observed virus protein-specific IgA and IgG responses with few defined signals, while IgM showed more signals, but without a clear trend. Therefore, we focused on IgA and IgG responses. To define a normal antibody background (negative).....
Document: To evaluate the kinetics of B-cell epitopes during the mild and severe course of COVID-19, we used full-proteome peptide microarrays (see Supporting Information for complete microarray data). As a general trend, we observed virus protein-specific IgA and IgG responses with few defined signals, while IgM showed more signals, but without a clear trend. Therefore, we focused on IgA and IgG responses. To define a normal antibody background (negative) on the microarray, we used a healthy donor sample (#5) as a All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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