Author: Jia Li; Patrizio Mazzone; Lisa Leung; Weiqian Lin; Giuseppe D'Angelo; Jun Ma; Jin Li; Zaki Akhtar; Yuechun Li; Paolo E Della Bella; Jiafeng Lin; Mark M Gallagher
Title: Electrophysiology in the time of coronavirus: coping with the great wave. Document date: 2020_3_30
ID: amj0ohw3_43
Snippet: Severe acute respiratory syndrome coronarvirus-2 (SARS-CoV-2), the agent responsible for COVID-19 has an affinity for angiotensin converting enzyme 2 (ACE2) receptors. 11 This is central to the pathophysiology of the condition, leading to pneumonia and in critical stages, associated fulminant acute respiratory distress syndrome (ARDS) and multi-organ failure. 12 The primary affected organ is the lung but cardiovascular injury is also common. Ther.....
Document: Severe acute respiratory syndrome coronarvirus-2 (SARS-CoV-2), the agent responsible for COVID-19 has an affinity for angiotensin converting enzyme 2 (ACE2) receptors. 11 This is central to the pathophysiology of the condition, leading to pneumonia and in critical stages, associated fulminant acute respiratory distress syndrome (ARDS) and multi-organ failure. 12 The primary affected organ is the lung but cardiovascular injury is also common. There is enhanced expression of ACE-2 in those with cardiovascular conditions, possibly accounting for the apparent greater severity of COVID-19 related illness in these patients. In one study, a majority (58%) of those with severe infection had a background of hypetension, and non-specifically 44% had a history of 'arrhythmia'. 13 Binding of the virus to ACE2 receptors in the lung and the heart initiates the acute inflammatory response. Pneumonia results, but also evidence of myocarditis; those with a rise in high-sensitivity Troponin I are more likely to require admission to intensive care. 14 There is a strong association between a history of hypertension and mortality from COVID-19. Systolic blood pressure was significantly higher in those with COVID-19 treated in intensive care units compared to those not requiring this level of care (144 versus 122, P<0.001). 14 This may relate to up-regulation of ACE2 receptors in those receiving ACE inhibiting drugs. All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
Search related documents:
Co phrase search for related documents- mortality hypertension and myocarditis evidence: 1
- mortality hypertension and respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- mortality hypertension and severe infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- mortality hypertension and systolic blood pressure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- multi organ failure and Pneumonia result: 1
- multi organ failure and respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- multi organ failure and responsible agent: 1
- multi organ failure and severe infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- myocarditis evidence and Pneumonia result: 1
- myocarditis evidence and respiratory distress syndrome: 1, 2, 3, 4
- myocarditis evidence and severe infection: 1, 2, 3, 4, 5, 6, 7, 8
- primary affected organ and respiratory distress syndrome: 1
- respiratory distress syndrome and severe infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- respiratory distress syndrome and strong association: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- respiratory distress syndrome and systolic blood pressure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- responsible agent and severe infection: 1, 2, 3, 4, 5
- severe infection and strong association: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- severe infection and systolic blood pressure: 1, 2, 3, 4, 5, 6, 7, 8, 9
- strong association and systolic blood pressure: 1, 2
Co phrase search for related documents, hyperlinks ordered by date