Selected article for: "mutation rate and SARS CoV mutation rate"
Author: Lin Li; Ting Sun; Yufei He; Wendong Li; Yubo Fan; Jing Zhang
Title: Epitope-based peptide vaccine design and target site characterization against novel coronavirus disease caused by SARS-CoV-2
  • Document date: 2020_2_27
    • ID: e9vq3fe3_34
    Snippet: We predict the B-and T-cell epitopes identified here may assist the development of potent peptide-based vaccines to address the SARS-CoV-2 challenge. But the replication of SARS-CoV-2 must be error-prone, which is similar to SARS-CoV with reported mutation rate of 4x10 -4 substitutions/site/year [29] . Antiviral vaccines are necessary to be developed before the predicted epitopes are potentially obsolete. In addition, our immune-informatics based.....
    Document: We predict the B-and T-cell epitopes identified here may assist the development of potent peptide-based vaccines to address the SARS-CoV-2 challenge. But the replication of SARS-CoV-2 must be error-prone, which is similar to SARS-CoV with reported mutation rate of 4x10 -4 substitutions/site/year [29] . Antiviral vaccines are necessary to be developed before the predicted epitopes are potentially obsolete. In addition, our immune-informatics based pipeline also provides a framework to identify B-and T-cell epitopes having therapeutic potential with excellent scope for SARS-CoV-2, but not limited to specific virus.

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