Author: Moreira, Ana C.; Mesquita, Gonçalo; Gomes, Maria Salomé
Title: Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions Cord-id: 6pyu36bq Document date: 2020_4_18
ID: 6pyu36bq
Snippet: Iron is an essential element for virtually all cell types due to its role in energy metabolism, nucleic acid synthesis and cell proliferation. Nevertheless, if free, iron induces cellular and organ damage through the formation of free radicals. Thus, iron levels must be firmly controlled. During infection, both host and microbe need to access iron and avoid its toxicity. Alterations in serum and cellular iron have been reported as important markers of pathology. In this regard, ferritin, first d
Document: Iron is an essential element for virtually all cell types due to its role in energy metabolism, nucleic acid synthesis and cell proliferation. Nevertheless, if free, iron induces cellular and organ damage through the formation of free radicals. Thus, iron levels must be firmly controlled. During infection, both host and microbe need to access iron and avoid its toxicity. Alterations in serum and cellular iron have been reported as important markers of pathology. In this regard, ferritin, first discovered as an iron storage protein, has emerged as a biomarker not only in iron-related disorders but also in inflammatory diseases, or diseases in which inflammation has a central role such as cancer, neurodegeneration or infection. The basic research on ferritin identification and functions, as well as its role in diseases with an inflammatory component and its potential as a target in host-directed therapies, are the main considerations of this review.
Search related documents:
Co phrase search for related documents- acute phase and adipose tissue: 1
- acute phase and liver cancer: 1
- acute phase and liver spleen: 1, 2, 3
- acute phase and liver steatosis: 1, 2
- acute phase and low mortality: 1, 2, 3
- acute phase and low production: 1
- acute phase and lps lipopolysaccharide: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute phase and lung macrophage: 1, 2
- acute phase and lung tumor: 1, 2
- acute phase and lupus erythematosus: 1, 2
- acute phase and lymphocyte function: 1
- adipose tissue and liver cancer: 1, 2
- adipose tissue and liver spleen: 1, 2, 3, 4, 5
- adipose tissue and liver steatosis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- adipose tissue and low mortality: 1, 2
- low mortality and lps induce: 1
- low mortality and lps lipopolysaccharide: 1
- low mortality and lung tumor: 1, 2
- low mortality and lupus erythematosus: 1
Co phrase search for related documents, hyperlinks ordered by date