Selected article for: "gene expression and protein expression"
Author: Shitao Rao; Alexandria Lau; Hon-Cheong So
Title: Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of 2019-nCov: A Mendelian Randomization analysis
  • Document date: 2020_3_8
    • ID: myh73pe6_14
    Snippet: Regarding the outcome, we are interested in the expression of ACE2. While ideally one should study the protein expression in the lung, such data is scarce and corresponding genotype data (required for MR) is not available. Here we focus on the gene expression of ACE2 in the lung (N = 515). ACE2 protein levels appear to be relatively well-correlated with mRNA levels across tissues, based on the Human Proteome Atlas (https://www.proteinatlas.org/EN.....
    Document: Regarding the outcome, we are interested in the expression of ACE2. While ideally one should study the protein expression in the lung, such data is scarce and corresponding genotype data (required for MR) is not available. Here we focus on the gene expression of ACE2 in the lung (N = 515). ACE2 protein levels appear to be relatively well-correlated with mRNA levels across tissues, based on the Human Proteome Atlas (https://www.proteinatlas.org/ENSG00000130234-ACE2/tissue). We retrieved GWAS summary data from the GTEx database, one of the largest databases to date with both genotype and expression data for a large variety of tissues. For details of GTEx please refer to 24 .

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