Selected article for: "assay sensitivity and specific test"
Author: Monika Abedin Sigg; Tabea Menchen; Jeffery Johnson; Chanjae Lee; Semil P. Choksi; Galo Garcia; Henriette Busengdal; Gerard Dougherty; Petra Pennekamp; Claudius Werner; Fabian Rentzsch; Nevan Krogan; John B. Wallingford; Heymut Omran; Jeremy F. Reiter
Title: Evolutionary proteomics uncovers ciliary signaling components
  • Document date: 2017_6_22
    • ID: 9y8r277c_17
    Snippet: Based on proportion of the human genome encoding known ciliary proteins, we expected that 1-271 3 proteins would localized to cilia. Four of the randomly selected proteins localized to cilia 272 ( Figure S1A) , suggesting that the test is specific. Of the 49 randomly selected candidate ciliary 273 proteins, 10 localized to the cilium or the ciliary base ( Figure 3C and S1B). Included in the 49 274 proteins were 8 SYSCILIA Gold Standard proteins, .....
    Document: Based on proportion of the human genome encoding known ciliary proteins, we expected that 1-271 3 proteins would localized to cilia. Four of the randomly selected proteins localized to cilia 272 ( Figure S1A) , suggesting that the test is specific. Of the 49 randomly selected candidate ciliary 273 proteins, 10 localized to the cilium or the ciliary base ( Figure 3C and S1B). Included in the 49 274 proteins were 8 SYSCILIA Gold Standard proteins, one of which localized to cilia, indicating 275 that this test is not sensitive. Based on the proportion of candidate ciliary proteins that localized 276 to cilia and the low sensitivity of the localization assay, greater than 20% of the proteins in the 277 high-confidence ciliome are likely to localize to human cilia. 278

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