Author: Said Mougari; Nisrine Chelkha; Dehia Sahmi-Bounsiar; Fabrizio Di Pinto; Philippe Colson; Jonatas Abrahao; Bernard La Scola
Title: First evidence of host range expansion in virophages and its potential impact on giant viruses and host cells Document date: 2019_9_24
ID: itxrhjns_6
Snippet: In this study, two recently isolated distant mimiviruses, known as Tupanvirus Deep Ocean and Tupanvirus Soda Lake, were challenged with virophages [20] [21] [22] . We report a preliminary identification of the first mechanism of host range expansion in virophages. We were able to characterize the genetic component involved in this process. We then conducted a comprehensive study to investigate the ecological impact of virophage host range expansi.....
Document: In this study, two recently isolated distant mimiviruses, known as Tupanvirus Deep Ocean and Tupanvirus Soda Lake, were challenged with virophages [20] [21] [22] . We report a preliminary identification of the first mechanism of host range expansion in virophages. We were able to characterize the genetic component involved in this process. We then conducted a comprehensive study to investigate the ecological impact of virophage host range expansion through its effect on the novel virus host as well as on the host cell population. The involvement of the mutation in host range expansion of the virophage is discussed.
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