Author: lianhua dong; Junbo Zhou; Chunyan Niu; Quanyi Wang; Yang Pan; Xia Wang; Yongzhuo zhang; Jiayi yang; Manqing Liu; Yang zhao; Tao peng; Jie xie; yunhua gao; Di wang; yun zhao; Xinhua Dai; xiang fang
Title: Highly accurate and sensitive diagnostic detection of SARS-CoV-2 by digital PCR Document date: 2020_3_18
ID: aa7slcnc_24
Snippet: Among the 103 specimens, 29 positive, 25 negative and 49 suspected were reported by RT-qPCR. However, 61 samples including 17 negative and 44 suspected tested by qPCR were confirmed to be positive by RT-dPCR, thus 90 patients in total whose SARS-CoV-2 nucleic acid were positive tested can be diagnosed with COVID-19. All the 103 patients were confirmed SARS-CoV-2 infection according to a follow-up survey. The sensitivity of SARS-CoV-2 detection wa.....
Document: Among the 103 specimens, 29 positive, 25 negative and 49 suspected were reported by RT-qPCR. However, 61 samples including 17 negative and 44 suspected tested by qPCR were confirmed to be positive by RT-dPCR, thus 90 patients in total whose SARS-CoV-2 nucleic acid were positive tested can be diagnosed with COVID-19. All the 103 patients were confirmed SARS-CoV-2 infection according to a follow-up survey. The sensitivity of SARS-CoV-2 detection was significantly improved from 28.2% to 87.4% for the 103 patients ( Fig. 2A and 2B ).
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