The effect of Hemoperfusion on Outcome, Clinical and Laboratory findings of Patients with Severe COVID-19: A Retrospective Study

Soleimani, Alireza; Moeini Taba, Seyed-Masoud; Hasibi Taheri, Sara; Loghman, Amir Hossein; Shayestehpour, Mohammad

Hemoperfusion is a method of blood filtering to remove toxins and inflammatory factors. Cytokine storms and high levels of inflammatory factors play a role in the pathogenesis of coronavirus disease 2019 (COVID-19). The present study aims to evaluate the effect of hemoperfusion on the clinical and laboratory findings and outcomes of patients with severe COVID-19. Forty-eight patients with severe COVID-19 and a positive PCR test who were admitted to the intensive care unit (ICU) participated in the study. All patients were treated by routine treatment protocol for COVID-19. Hemoperfusion was performed for 24 patients in addition to treatment with conventional antiviral therapies. The other 24 patients made up the control group. Demographic data, laboratory findings, and patient outcomes before and after treatment were retrospectively collected and analyzed. There was no significant difference in mortality or length of hospital stays between the control group and the hemoperfusion group. The breathing rate (P-value=0.001) and heart beat rate (P-value=0.028) of patients decreased after hemoperfusion. The hemoperfusion resulted in a significant increase in the SpO2 levels and a significant decrease in the CRP of patients compared to the conventional treatment (P-value=0.009). Hemoperfusion can improve respiratory distress. It can reduce the CRP in patients with severe COVID-19 but has no effect on mortality.